The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well lead to a rise in methadone plasma concentrations, which could trigger possibly lethal respiratory melancholy. On top of that, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also end in a